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Anti-SUMO2/3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Small ubiquitin-related modifier 2,3 is a protein that in humans is encoded by the SUMO2,3 gene. This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Synonyms

CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD81; Cd81; Tapa1

Gene Name

SUMO2/3

Gene ID

6613/6612

UniProt

P61956/P55854

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SUMO2/3 recombinant protein (Position: Q24-T72) .

Clonality

Polyclonal

Tissue Specificity

Expressed in oocytes. Highly expressed in granulosa cells.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Host-Virus Interaction, Human Protein, Immunology, Interspecies Interaction, Microbiology, Protein

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.

References & Citations

1. Adams, M. D., Soares, M. B., Kerlavage, A. R., Fields, C., Venter, J. C. Rapid cDNA sequencing (expressed sequence tags) from a ionally cloned human infant brain cDNA library. Nature Genet. 4: 373-380, 1993. 2. Dai, K.-S., Liew, C.-C. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. J. Biol. Chem. 276: 23992-23999, 2001. 3. Lapenta, V., Chiurazzi, P., van der Spek, P., Pizzuti, A., Hanaoka, F., Brahe, C. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. Genomics 40: 362-366, 1997.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

CD81 antigen

Subcellular Location

Basolateral cell membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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