Anti-Slc7a9 Antibody Picoband®

B (0, +) -type amino acid transporter 1, also known as b (0, +) AT1, is a protein which in humans is encoded by the SLC7A9 gene. This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene.

Pulmonary surfactant-associated protein B; SP-B; 18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL (Phe) ; SFTPB; SFTP3

Cancer, Cardiovascular, Cell Biology, Cell Cycle, Cell Differentiation, Lipases, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction, Vasculature

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

1. Brodehl, J., Gellissen, K., Kowalewski, S. Isolierter Defekt der tubulaeren Cystin-Rueckresorption in einer Familie mit idiopathischem Hypoparathyroidismus. Klin. Wschr. 45: 38-40, 1967. 2. Colombo, R. Dating the origin of the V170M mutation causing non-type I cystinuria in Libyan Jews by linkage disequilibrium and physical mapping of the SLC7A9 gene. Genomics 69: 131-134, 2000. 3. Dello Strologo, L., Pras, E., Pontesilli, C., Beccia, E., Ricci-Barbini, V., de Sanctis, L., Ponzone, A., Gallucci, M., Bisceglia, L., Zelante, L., Jimenez-Vidal, M., Font, M., Zorzano, A., Rousaud, F., Nunes, V., Gasparini, P., Palacin, M., Rizzoni, G. Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J. Am. Soc. Nephrol. 13: 2547-2553, 2002.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.