Anti-Psmb1 Antibody Picoband® Fluoro647 Conjugated

Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB1 gene. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.

Disintegrin and metalloproteinase domain-containing protein 28; ADAM 28;3.4.24.-; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L; ADAM28; ADAM23, MDCL

Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.

May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.

1. Okumura, K., Nogami, M., Taguchi, H., Hisamatsu, H., Tanaka, K. The genes for the alpha-type HC3 (PMSA2) and beta-type HC5 (PMSB1) subunits of human proteasomes map to chromosomes 6q27 and 7p12-p13 by fluorescence in situ hybridization. Genomics 27: 377-379, 1995. 2. Tamura, T., Osaka, F., Kawamura, Y., Higuti, T., Ishida, N., Nothwang, H.-G., Tsurumi, C., Tanaka, K., Ichihara, A. Isolation and characterization of alpha-type HC3 and beta-type HC5 subunit genes of human proteasomes. J. Molec. Biol. 244: 117-124, 1994. 3. Trachtulec, Z., Hamvas, R. M. J., Forejt, J., Lehrach, H. R., Vincek, V., Klein, J. Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. Genomics 44: 1-7, 1997.