Anti-p38 gamma/MAPK12 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
Synonyms
Fos-related antigen 1; FRA-1; FOSL1; FRA1
Gene Name
MAPK12
Gene ID
6300
UniProt
P53778
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MAPK12 recombinant protein (Position: S229-L367) .
Clonality
Polyclonal
Tissue Specificity
Adipocytes.
Applications
Flow Cytometry
Field of Research
Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription, Transcription Factors
Purification
Immunogen affinity purified.
Form
Liquid
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
References & Citations
1. Goedert, M., Hasegawa, J., Craxton, M., Leversha, M. A., Clegg, S. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. Genomics 41: 501-502, 1997. 2. Lechner, C., Zahalka, M. A., Giot, J.-F., Moller, N. P. H., Ullrich, A. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Nat. Acad. Sci. 93: 4355-4359, 1996. 3. Li, Z., Jiang, Y., Ulevitch, R. J., Han, J. The primary structure of p38-gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228: 334-340, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
FOS like 1, AP-1 transcription factor subunit
Subcellular Location
Nucleus.
Protein Name
Eukaryotic initiation factor 4A-I
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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