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Anti-KCNQ2 Antibody Picoband® Fluoro594 Conjugated

Selected Variant

A01259-1-Fluoro594

Size: 100 µg/Vial

Product Specifications

Background

KCNQ2, also called kv7.2, is a potassium channel protein coded for by the gene KCNQ2. It is mapped to 20q13.33. The KCNQ2 gene encodes a voltage-gated potassium channel that is expressed in the brain. Expression of human KCNQ2 in Xenopus laevis oocytes led to potassium-selective currents that activated slowly with depolarization. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1) . At least five transcript variants encoding five different isoforms have been found for this gene.

Synonyms

Four and a half LIM domains protein 1; FHL-1; KyoT; RBP-associated molecule 14-1; RAM14-1; Skeletal muscle LIM-protein 1; SLIM; SLIM-1

Gene Name

KCNQ2

Gene ID

3785

UniProt

O43526

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human KCNQ2 recombinant protein (Position: M371-D408) .

Clonality

Polyclonal

Tissue Specificity

Isoform 1 seems to be most abundant in each tissue and isoform 2 much less abundant. Isoform 1 is highly expressed in skeletal muscle and lung, and to a lesser extent in heart, brain and kidney. Isoform 2 was found in brain, lung kidney and genital organs.

Applications

Flow Cytometry

Field of Research

Cytokines, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Immunology, Innate Immunity, Stem Cells, Surface Molecules

Purification

Immunogen affinity purified.

Form

Liquid

Function

May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.

References & Citations

1. Biervert, C., Schroeder, B. C., Kubisch, C., Berkovic, S. F., Propping, P., Jentsch, T. J., Steinlein, O. K. A potassium channel mutation in neonatal human epilepsy. Science 279: 403-406, 1998. 2. Entrez Gene: KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 3. Heron, S. E., Cox, K., Grinton, B. E., Zuberi, S. M., Kivity, S., Afawi, Z., Straussberg, R., Berkovic, S. F., Scheffer, I. E., Mulley, J. C. Deletions or duplications in KCNQ2 can cause benign familial neonatal seizures. (Letter) J. Med. Genet. 44: 791-796, 2007.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Four and a half LIM domains 1

Subcellular Location

Cell membrane. Single-pass type II membrane protein. Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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