Anti-LRP1B Antibody

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene. This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer.

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .

1. Liu, C.-X., Li, Y., Obermoeller-McCormick, L. M., Schwartz, A. L., Bu, G. The putative tumor suppressor LRP1B, a novel member of the low absorbance lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J. Biol. Chem. 276: 28889-28896, 2001. 2. Liu, C.-X., Musco, S., Lisitsina, N. M., Forgacs, E., Minna, J. D., Lisitsyn, N. A. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. Cancer Res. 60: 1961-1967, 2000. 3. Liu, C.-X., Musco, S., Lisitsina, N. M., Yaklichkin, S. Y., Lisitsyn, N. A. Genomic organization of a new candidate tumor suppressor gene, LRP1B. Genomics 69: 271-274, 2000.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.