What sizes are available for Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated?

Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated in stock?

Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-ZIC3 Antibody Picoband® Fluoro647 Conjugated is A04050-2-Fluoro647.

Selected Variant

A04050-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

ZIC3 is a member of the Zinc finger of the cerebellum (ZIC) protein family. This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.

Synonyms

Microtubule-associated tumor suppressor 1; AT2 receptor-binding protein; Angiotensin-II type 2 receptor-interacting protein; Mitochondrial tumor suppressor 1; MTUS1; ATBP; ATIP; GK1; KIAA1288; MTSG1

Gene Name

ZIC3

Gene ID

7547

UniProt

O60481

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ZIC3 recombinant protein (Position: N113-N455) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed (at protein level) . Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC) . Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, Transcription, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.

References & Citations

1. Aruga, J., Nagai, T., Tokuyama, T., Hayashizaki, Y., Okazaki, Y., Chapman, V. M., Mikoshiba, K. The mouse Zic gene family: homologues of the Drosophila pair-rule gene odd-paired. J. Biol. Chem. 271: 1043-1047, 1996. 2. Bedard, J. E. J., Purnell, J. D., Ware, S. M. Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3. Hum. Molec. Genet. 16: 187-198, 2007. 3. Burdine, R. D., Schier, A. F. Conserved and divergent mechanisms in left-right axis formation. Genes Dev. 14: 763-776, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

23310 MW

Applications Notes

Gene Name Synonym

Microtubule associated scaffold protein 1

Subcellular Location

Mitochondrion. Golgi apparatus. Cell membrane. Nucleus.

Protein Name

Ran-specific GTPase-activating protein

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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