Anti-Astrin/Deepest/SPAG5 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene. This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
Synonyms
Mimecan; Osteoglycin; Ogn; Og
Gene Name
SPAG5
Gene ID
10615
UniProt
Q96R06
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Astrin/Deepest/SPAG5 recombinant protein (Position: E738-S1193) .
Clonality
Polyclonal
Tissue Specificity
Expressed in kidney.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures
Purification
Immunogen affinity purified.
Form
Liquid
Function
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
References & Citations
1. Chang, M.-S., Huang, C.-J., Chen, M.-L., Chen, S.-T., Fan, C.-C., Chu, J.-M., Lin, W.-C., Yang, Y.-C. Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins. Biochem. Biophys. Res. Commun. 287: 116-121, 2001. 2. Cheng, T.-S., Hsiao, Y.-L., Lin, C.-C., Yu, C.-T. R, Hsu, C.-M., Chang, M.-S., Lee, C.-I., Huang, C.-Y. F., Howng, S.-L., Hong, Y.-R. Glycogen synthase kinase 3-beta interacts with and phosphorylates the spindle-associated protein astrin. J. Biol. Chem. 283: 2454-2464, 2008. 3. Du, J., Jablonski, S., Yen, T. J., Hannon, G. J. Astrin regulates Aurora-A localization. Biochem. Biophys. Res. Commun. 370: 213-219, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Osteoglycin
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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