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Anti-SEC14L3/TAP2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

Gene Name

SEC14L3

Gene ID

266629

UniProt

Q9UDX4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human SEC14L3/TAP2 recombinant protein (Position: R4-V400) .

Clonality

Polyclonal

Tissue Specificity

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Applications

Flow Cytometry

Field of Research

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

References & Citations

1. Kempna, P., Zingg, J.-M., Ricciarelli, R., Hierl, M., Saxena, S., Azzi, A. Cloning of novel human Sec14p-like proteins: ligand binding and functional properties. Free Radic. Biol. Med. 34: 1458-1472, 2003. 2. Ye, X., Ji, C., Yin, G., Tang, R., Zeng, L., Gu, S., Ying, K., Xie, Y., Zhao, R. C., Mao, Y. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Molec. Biol. Rep. 31: 59-63, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64099 MW

Applications Notes

6

Gene Name Synonym

RNA-binding protein 47

Subcellular Location

Nucleus .

Protein Name

Follicular dendritic cell secreted peptide

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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