Anti-MIEF1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Mitochondrial dynamic protein MID51 (MID51) also known as mitochondrial elongation factor 1 (MIEF1) or Smith-Magenis syndrome chromosome region candidate gene 7 protein-like (SMCR7L) is a protein that in humans is encoded by the SMCR7L gene. The SMCR7L gene codes for a protein that has been called MiD51/MIEF1 and shown to regulate mitochondrial fission by interacting with the proteins Drp1 and FIS1.
Synonyms
Disintegrin and metalloproteinase domain-containing protein 28; ADAM 28;3.4.24.-; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L; ADAM28; ADAM23, MDCL
Gene Name
MIEF1
Gene ID
54471
UniProt
Q9NQG6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MIEF1 recombinant protein (Position: S189-T463) .
Clonality
Polyclonal
Tissue Specificity
Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 10/25/2013. 2. Palmer, C. S., Elgass, K. D., Parton, R. G., Osellame, L. D., Stojanovski, D., Ryan, M. T. Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J. Biol. Chem. 288: 27584-27593, 2013. 3. Palmer, C. S., Osellame, L. D., Laine, D., Koutsopoulos, O. S., Frazier, A. E., Ryan, M. T. MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep. 12: 565-573, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51 kDa
Applications Notes
6
Gene Name Synonym
ADAM metallopeptidase domain 28
Subcellular Location
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Protein Name
ADAM metallopeptidase domain 28
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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