Anti-Cox6a2 Antibody Picoband® Fluoro488 Conjugated

Cytochrome c oxidase subunit VIa polypeptide 2 is a protein that in humans is encoded by the COX6A2 gene. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.

A synthetic peptide corresponding to a sequence in the middle region of mouse Cox6a2, which shares 66.7% and 100% amino acid (aa) sequence identity with human and rat Cox6a2, respectively.

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Bachman, N. J., Riggs, P. K., Siddiqui, N., Makris, G. J., Womack, J. E., Lomax, M. I. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. Genomics 42: 146-151, 1997. 2. Inoue, M., Uchino, S., Iida, A., Noguchi, S., Hayashi, S., Takahashi, T., Fujii, K., Komaki, H., Takeshita, E., Nonaka, I., Okada, Y., Yoshizawa, T., Van Lommel, L., Schuit, F., Goto, Y., Mimaki, M., Nishino, I. COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency. Ann. Neurol. 86: 193-202, 2019. 3. Quintens, R., Singh, S., Lemaire, K., De Bock, K., Granvik, M., Schraenen, A., Vroegrijk, I. O. C. M., Costa, V., Van Noten, P., Lambrechts, D., Lehnert, S., Van Lommel, L., and 10 others. Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One 8: e56719, 2013. Note: Electronic Article.