Anti-Coronin 1a/TACO/CORO1A Antibody Picoband® Fluoro488 Conjugated
Selected Variant
A04245-2-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
Coronin-1A is a protein that in humans is encoded by the CORO1A gene. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
Synonyms
Low affinity immunoglobulin epsilon Fc receptor; BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD23; Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; FCER2; CD23A; CLEC4J; FCE2; IGEBF
Gene Name
CORO1A
Gene ID
11151
UniProt
P31146
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Coronin 1a/TACO/CORO1A recombinant protein (Position: E173-K461) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) .
References & Citations
1. Ferrari, G., Langen, H., Naito, M., Pieters, J. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 97: 435-447, 1999. 2. Foger, N., Rangell, L., Danilenko, D. M., Chan, A. C. Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis. Science 313: 839-842, 2006. 3. Haraldsson, M. K., Louis-Dit-Sully, C. A., Lawson, B. R., Sternik, G., Santiago-Raber, M.-L., Gascoigne, N. R. J., Theofilopoulos, A. N., Kono, D. H. The lupus-related Lmb3 locus contains a disease-suppressing coronin-1A gene mutation. Immunity 28: 40-51, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Fc fragment of IgE, low affinity II, receptor for (CD23)
Subcellular Location
Cell membrane; Also exists as a soluble excreted form, sCD23.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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