Anti-TNIP1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene. This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD270; TNFRSF14; HVEA, HVEM; UNQ329/PRO509
Gene Name
TNIP1
Gene ID
10318
UniProt
Q15025
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human TNIP1 recombinant protein (Position: E312-K371) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed, with the highest expression in lung, spleen and thymus.
Applications
Flow Cytometry
Field of Research
Antiviral Signaling, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Innate Immunity, Signal Transduction, TNF Superfamily
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. .
References & Citations
1. El Bakkouri, K., Wullaert, A., Haegman, M., Heyninck, K., Beyaert, R. Adenoviral gene transfer of the NK-kappa-B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model. J. Biol. Chem. 280: 17938-17944, 2005. 2. Fukushi, M., Dixon, J., Kimura, T., Tsurutani, N., Dixon, M. J., Yamamoto, N. Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression. FEBS Lett. 442: 83-88, 1999. 3. Oshima, S., Turer, E. E., Callahan, J. A., Chai, S., Advincula, R., Barrera, J., Shifrin, N., Lee, B., Yen, B., Woo, T., Malynn, B. A., Ma, A. ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature 457: 906-909, 2009. Note: Erratum: Nature 458: 538 only, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
30392 MW
Applications Notes
6
Gene Name Synonym
Tumor necrosis factor receptor superfamily member 14
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Protein Name
Tumor necrosis factor receptor superfamily member 14
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog