Anti-Raptor/RPTOR Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Glutathione S-transferase A1; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1; Glutathione S-transferase A1, N-terminally processed; GSTA1
Gene Name
RPTOR
Gene ID
57521
UniProt
Q8N122
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Raptor/RPTOR recombinant protein (Position: R301-R358) .
Clonality
Polyclonal
Tissue Specificity
Liver.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
References & Citations
1. Aylett, C. H. S., Sauer, E., Imseng, S., Boehringer, D., Hall, M. N., Ban, N., Maier, T. Architecture of human mTOR complex 1. Science 351: 48-52, 2016. 2. Capon, F., Helms, C., Veal, C. D., Tillman, D., Burden, A. D., Barker, J. N., Bowcock, A. M., Trembath, R. C. Genetic analysis of PSORS2 markers in a UK dataset supports the association between RAPTOR SNPs and familial psoriasis. (Letter) J. Med. Genet. 41: 459-460, 2004. 3. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., Yonezawa, K. Raptor, a binding partner of target of rapamycin, mediates TOR action. Cell 110: 177-189, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25722 MW
Applications Notes
6
Gene Name Synonym
Glutathione S-transferase alpha 1/2/3/4/5
Subcellular Location
Cytoplasm.
Protein Name
Glutathione S-transferase A1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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