Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-PRDM14 Antibody Picoband®

Boster Bio Anti-PRDM14 Antibody Picoband® catalog # A03870-2. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.

Synonyms

AF4/FMR2 family member 4; ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein; AFF4; AF5Q31, MCEF; HSPC092

Gene Name

PRDM14

Gene ID

63978

UniProt

Q9GZV8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human PRDM14, which shares 55.2% amino acid (aa) sequence identity with mouse PRDM14.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain. .

Applications

Flow Cytometry, IF, IHC, ICC, WB

Field of Research

Epigenetics and Nuclear Signaling, Transcription, Cell Biology, Transcription Factors, Cell Cycle

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. .

References & Citations

1. Chia, N.-Y., Chan, Y.-S., Feng, B., Lu, X., Orlov, Y. L., Moreau, D., Kumar, P., Yang, L., Jiang, J., Lau, M.-S., Huss, M., Soh, B.-S., Kraus, P., Li, P., Lufkin, T., Lim, B., Clarke, N. D., Bard, F., Ng, H.-H. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468: 316-320, 2010. 2. Jiang, G.-L., Huang, S. The yin-yang of PR-domain family genes in tumorigenesis. Histol. Histopath. 15: 109-117, 2000. 3. Nakaki, F., Hayashi, K., Ohta, H., Kurimoto, K., Yabuta, Y., Saitou, M. Induction of mouse germ-cell fate by transcription factors in vitro. Nature 501: 222-226, 2013.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

127459 MW

Observed Molecular Weight

64 kDa

Applications Notes

6

Gene Name Synonym

AF4/FMR2 family member 4

Subcellular Location

Nucleus . Associates to transcriptionally active chromatin but not at snRNA genes. .

Protein Name

AF4/FMR2 family member 4

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RBBP6 Polyclonal Antibody
bs-6576R 100 µL

RBBP6 Polyclonal Antibody

Ask
View Details
RPL37P4 CRISPR All-in-one AAV vector set (with saCas9)(Human)
41635151 3x 1.0 µg DNA

RPL37P4 CRISPR All-in-one AAV vector set (with saCas9)(Human)

Ask
View Details
Sodium Bromide 99.4% ACS
GPC9436-2.5Y 2.5 Kg

Sodium Bromide 99.4% ACS

Ask
View Details
Genesig Real-Time PCR detection kit for Crimean-Congo Haemorrhagic Fever Virus, Advanced
348900 1 Kit

Genesig Real-Time PCR detection kit for Crimean-Congo Haemorrhagic Fever Virus, Advanced

Ask
View Details
Cep89 (NM_001127599) Rat Tagged ORF Clone
RR209462 10 µg

Cep89 (NM_001127599) Rat Tagged ORF Clone

Ask
View Details
Anti-FBL5 Antibody
CQA1241-01 30 µL

Anti-FBL5 Antibody

Ask
View Details