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Anti-PFAS Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis.

Synonyms

S-arrestin; 48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin; SAG

Gene Name

PFAS

Gene ID

5198

UniProt

O15067

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PFAS recombinant protein (Position: R330-S569) .

Clonality

Polyclonal

Tissue Specificity

Retina and pineal gland.

Applications

Flow Cytometry

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, Nucleus, RNA Processing, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Arrestin is one of the major proteins of the ros (retinal rod outer segments) ; it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

References & Citations

1. Barnes, T. S., Bleskan, J. H., Hart, I. M., Walton, K. A., Barton, J. W., Patterson, D. Purification of, generation of monoclonal antibodies to, and mapping of phosphoribosyl N-formylglycinamide amidotransferase. Biochemistry 33: 1850-1860, 1994. 2. Brodsky, G., Barnes, T., Bleskan, J., Becker, L., Cox, M., Patterson, D. The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome. Hum. Molec. Genet. 6: 2043-2050, 1997.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64133 MW

Applications Notes

6

Gene Name Synonym

S-antigen visual arrestin

Subcellular Location

Nucleus, nucleoplasm . Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. .

Protein Name

Heterogeneous nuclear ribonucleoprotein L

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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