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Anti-ARF6 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

ADP-ribosylation factor 6 (ARF6) is a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.

Synonyms

Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; Igfbp1; Igfbp-1

Gene Name

ARF6

Gene ID

382

UniProt

P62330

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human ARF6 recombinant protein (Position: R75-S175) .

Clonality

Polyclonal

Tissue Specificity

High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Diabetes-associated, Growth Factors, Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity) . .

References & Citations

1. Entrez Gene: ARF6 ADP-ribosylation factor 6. 2. Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P (December 2003) . ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J. Cell Biol. 163 (5) : 1111–21. 3. Peru y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A (December 2012) .Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.J. Neurosci. 32 (49) : 17706–13.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

27904 MW

Applications Notes

6

Gene Name Synonym

Insulin-like growth factor binding protein 1

Subcellular Location

Secreted.

Protein Name

Insulin-like growth factor-binding protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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