Anti-IRF3 Antibody Picoband® (monoclonal, 7B10) Fluoro488 Conjugated
Product Specifications
Background
Reporter gene
Synonyms
Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter; SLC2A1; GLUT1
Gene Name
Irf3
Gene ID
54131
UniProt
P70671
Host
Mouse
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse IRF3 recombinant protein (Position: M1-I419) .
Clonality
Monoclonal
Clone
Clone: 7B10
Tissue Specificity
Detected in erythrocytes (at protein level) . Expressed at variable levels in many human tissues.
Applications
Flow Cytometry
Field of Research
Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
References & Citations
1. Bellingham, J., Gregory-Evans, K., Gregory-Evans, C. Y. Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann. Hum. Genet. 62: 231-234, 1998. 2. Doyle, S. E., Vaidya, S. A., O'Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T.-T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G.IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17: 251-263, 2002. 3. Stetson, D. B., Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
46659 MW
Applications Notes
6
Gene Name Synonym
Solute carrier family 2 (facilitated glucose transporter), member 1
Subcellular Location
Cell membrane. Multi-pass membrane protein. Melanosome.
Protein Name
Isocitrate dehydrogenase [NADP] cytoplasmic
Isotype
Mouse IgG2b
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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