Anti-Uroplakin Ib/UPIb Antibody Picoband® Fluoro488 Conjugated

Uroplakin 1B, also known as UPK1B, is a protein which in humans is encoded by the UPK1B gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.

1. Finch, J. L., Webb, G. C., Evdokiou, A, Cowled, P. A. Chromosomal localization of the human urothelial tetraspan gene, UPK1B, to 3q13.3-q21 and detection of a Taq1 polymorphism. Genomics 40: 501-503, 1997. 2. Lobban, E. D., Smith, B. A., Hall, G. D., Harnden, P., Roberts, P., Selby, P. J., Trejdosiewicz, L. K., Southgate, J. Uroplakin gene expression by normal and neoplastic human urothelium. Am. J. Path. 153: 1957-1967, 1998. 3. Olsburgh, J., Weeks, R., Selby, P., Southgate, J. Human uroplakin 1b gene structure and promoter analysis. Biochim. Biophys. Acta 1576: 163-170, 2002. 4. Webb, G. C., Finch, J. L., Cowled, P. A. Assignment of the uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization. Cytogenet. Cell Genet. 84: 37-38, 1999.