Anti-SV2A Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene. The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons.
Synonyms
Sodium/glucose cotransporter 2; Na (+) /glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2; SLC5A2; SGLT2
Gene Name
SV2A
Gene ID
9900
UniProt
Q7L0J3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SV2A, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.
References & Citations
1. Bajjalieh, S. M., Peterson, K., Linial, M., Scheller, R. H. Brain contains two forms of synaptic vesicle protein 2. Proc. Nat. Acad. Sci. 90: 2150-2154, 1993. 2. Crowder, K. M., Gunther, J. M., Jones, T. A., Hale, B. D., Zhang, H. Z., Peterson, M. R., Scheller, R. H., Chavkin, C., Bajjalieh, S. M. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A) . Proc. Nat. Acad. Sci. 96: 15268-15273, 1999. 3. Dong, M., Yeh, F., Tepp, W. H., Dean, C., Johnson, E. A., Janz, R., Chapman, E. R. SV2 is the protein receptor for botulinum neurotoxin A. Science 312: 592-596, 2006.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Solute carrier family 5 member 2
Subcellular Location
Membrane. Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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