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Anti-AGO3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Synonyms

NADH-ubiquinone oxidoreductase chain 4; NADH dehydrogenase subunit 4; Mtnd4; mt-Nd4; Nd4

Gene Name

AGO3

Gene ID

192669

UniProt

Q9H9G7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human AGO3 recombinant protein (Position: M1-S181) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Applications

Flow Cytometry

Field of Research

Cell Type Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

References & Citations

1. Azuma-Mukai, A., Oguri, H., Mituyama, T., Qian, Z. R., Asai, K., Siomi, H., Siomi, M. C. Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. Proc. Nat. Acad. Sci. 105: 7964-7969, 2008. 2. Carmell, M. A., Xuan, Z., Zhang, M. Q., Hannon, G. J. The argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 16: 2733-2742, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

97 kDa

Applications Notes

6

Gene Name Synonym

NADH dehydrogenase 4, mitochondrial

Subcellular Location

Mitochondrion membrane. Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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