Anti-SARS-CoV-2 ORF8 Antibody Fluoro488 Conjugated
Product Specifications
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19) . Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ ORF8 encodes a viral accessory protein.
Synonyms
ORF8 protein; ORF8; Non-structural protein 8; ns8
Gene Name
8
Gene ID
43740577
UniProt
P0DTC8
Host
Rabbit
Reactivity
Human
Immunogen
AAFHQECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSFYEDFLEYHDVRVVLDFI
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. .
Applications
Flow Cytometry
Field of Research
Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
References & Citations
1. Gordon DE, et al. Nature, 2020 Jul. 2. Gordon DE, et al. Science, 2020 Oct 15. 3. Li JY, et al. Virus Res, 2020 Sep. 4. Wu F, et al. Nature, 2020 Mar.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
16693 MW
Applications Notes
6
Gene Name Synonym
ORF8 protein
Subcellular Location
Cytoplasm .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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