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Anti-CDC45L Picoband® Antibody (monoclonal, 6H6) Fluoro488 Conjugated

Product Specifications

Background

CDC45 is a protein that in humans is encoded by the CDC45L gene. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.

Synonyms

Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18; PIG46

Gene Name

CDC45

Gene ID

8318

UniProt

O75419

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human CDC45L recombinant protein (Position: E166-A431) .

Clonality

Monoclonal

Clone

Clone: 6H6

Tissue Specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Applications

Flow Cytometry

Field of Research

DNA/RNA, DNA Damage & Repair, DNA Damage Response, DNA Synthesis, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6) -mediated barrier protection.

References & Citations

1. Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae) . 2. McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ (Sep 1998) . selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 8 (8) : 834–41. 3. Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A (Aug 1998) . The human homolog of Saccharomyces cerevisiae CDC45. J. Biol. Chem. 273 (29) : 18205–9.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Keratin 18

Subcellular Location

Nucleolus. Perinuclear region.

Protein Name

Keratin, type I cytoskeletal 18

Isotype

Mouse IgG1

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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