Anti-XRCC2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
Synonyms
DNA repair protein XRCC2; X-ray repair cross-complementing protein 2; Xrcc2
Gene Name
XRCC2
Gene ID
7516
UniProt
O43543
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human XRCC2 recombinant protein (Position: A4-E106) .
Clonality
Polyclonal
Tissue Specificity
Expressed at low level in somatic tissues and at high level in testis.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
References & Citations
1. Braybrooke, J. P., Spink, K. G., Thacker, J., Hickson, I. D. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. J. Biol. Chem. 275: 29100-29106, 2000. 2. Deans, B., Griffin, C. S., Maconochie, M., Thacker, J. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J. 19: 6675-6685, 2000. 3. Johnson, R. D., Liu, N., Jasin, M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature 401: 397-399, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
X-ray repair complementing defective repair in Chinese hamster cells 2
Subcellular Location
Nucleus.
Protein Name
DNA repair protein XRCC2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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