Anti-SCG10/STMN2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Stathmin-2 is a protein that in humans is encoded by the STMN2 gene. This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6.
Synonyms
Homeobox protein Hox-B1; Homeobox protein Hox-2I; HOXB1; HOX2I
Gene Name
STMN2
Gene ID
11075
UniProt
Q93045
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human SCG10/STMN2 recombinant protein (Position: S23-N170) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
References & Citations
1. Bahn, S., Mimmack, M., Ryan, M., Caldwell, M. A., Jauniaux, E., Starkey, M., Svendsen, C. N., Emson, P. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 359: 310-315, 2002. 2. Okazaki, T., Yoshida, B. N., Avraham, K. B., Wang, H., Wuenschell, C. W., Jenkins, N. A., Copeland, N. G., Anderson, D. J., Mori, N. Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics 18: 360-373, 1993. Note: Erratum: Genomics 21: 298 only, 1994. 3. Stein, R., Mori, N., Matthews, K., Lo, L.-C., Anderson, D. J. The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons. Neuron 1: 463-476, 1988.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
32193 MW
Applications Notes
6
Gene Name Synonym
Ubiquitin conjugating enzyme E2 D1/2/3/4
Subcellular Location
Nucleus.
Protein Name
Ubiquitin-conjugating enzyme E2 D1/2/3/4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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