Anti-GRSF1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
G-rich sequence factor 1 (GRSF1) is a regulator of post-transcriptional mitochondrial gene expression. The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16
Gene Name
GRSF1
Gene ID
2926
UniProt
Q12849
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GRSF1 recombinant protein (Position: Q119-M405) .
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Applications
Flow Cytometry
Field of Research
Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
References & Citations
1. Banga, S. S., Ozer, H. L., Wilusz, J. Assignment of GRSF1 encoding a poly (A) + mRNA binding protein to human chromosome 4q13. Cytogenet. Cell Genet. 73: 295-296, 1996. 2. Qian, Z., Wilusz, J. GRSF-1: a poly (A) + mRNA binding protein which interacts with a conserved G-rich element. Nucleic Acids Res. 22: 2334-2343, 1994. 3. Qian, Z., Wilusz, J. An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal. Molec. Cell. Biol. 11: 5312-5320, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A07576-2-Fluoro647
Calculated Molecular Weight
157578 MW
Applications Notes
6
Gene Name Synonym
C-C motif chemokine ligand 16
Subcellular Location
Secreted.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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