Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-H Cadherin/CDH13 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

T-cadherin also known as cadherin 13, H-cadherin (heart) (CDH13) is a unique member of cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

Neuronal acetylcholine receptor subunit alpha-3; CHRNA3; NACHRA3

Gene Name

CDH13

Gene ID

1012

UniProt

P55290

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human H Cadherin/CDH13 recombinant protein (Position: E149-A692) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Immunology, T Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

References & Citations

1. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998. 2. Lee, S. W. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nature Med. 2: 776-782, 1996. 3. Sato, M., Mori, Y., Sakurada, A., Fujimura, S., Horii, A. The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum. Genet. 103: 96-101, 1998. Note: Erratum: Hum. Genet. 103: 532 only, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01986-1-Fluoro488

Applications Notes

6

Gene Name Synonym

Cholinergic receptor nicotinic alpha 3 subunit

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-01 0.1 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details
Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-02 0.2 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details
Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-03 0.5 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details
Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-04 1 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details
Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-05 5 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details
Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)
MBS2028161-06 5x 5 mL

Polyclonal Antibody to Matrix Metalloproteinase 19 (MMP19)

Ask
View Details