Anti-K Cadherin/CDH6 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Cadherin-6 is a protein that in humans is encoded by the CDH6 gene. This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.
Synonyms
Rho-related GTP-binding protein Rho6; Rho family GTPase 1; Rnd1; RND1; RHO6
Gene Name
CDH6
Gene ID
1004
UniProt
P55285
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human K Cadherin/CDH6 recombinant protein (Position: N153-H424) .
Clonality
Polyclonal
Tissue Specificity
Mostly expressed in brain and liver.
Applications
Flow Cytometry
Field of Research
Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, G Protein Signaling, Microfilaments, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. .
References & Citations
1. Chalmers, I. J., Hofler, H., Atkinson, M. J. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics 57: 160-163, 1999. 2. Shimoyama, Y., Gotoh, M., Terasaki, T., Kitajima, M., Hirohashi, S. Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. Cancer Res. 55: 2206-2211, 1995. 3. Suzuki, S., Sano, K., Tanihara, H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul. 2: 261-270, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
26056 MW
Applications Notes
6
Gene Name Synonym
Rho-related GTP-binding protein Rho6
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton .
Protein Name
AP-2 complex subunit mu
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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