Anti-AFAP/AFAP1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene. The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; RIPE3b1 factor; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA
Gene Name
AFAP1
Gene ID
60312
UniProt
Q8N556
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human AFAP/AFAP1 recombinant protein (Position: A498-T730) .
Clonality
Polyclonal
Tissue Specificity
Preferentially expressed in regulatory T-cells (Tregs) .
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.
References & Citations
1. Baisden, J. M., Qian, Y., Zot, H. M., Flynn, D. C. The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. Oncogene 20: 6435-6447, 2001. 2. Flynn, D. C., Leu, T. H., Reynolds, A. B., Parsons, J. T. Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Molec. Cell Biol. 13: 7892-7900, 1993. 3. Kanner, S. B., Reynolds, A. B., Wang, H.-C. R., Vines, R. R., Parsons, J. T. The SH2 and SH3 domains of pp60src stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J. 10: 1689-1698, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39411 MW
Applications Notes
6
Gene Name Synonym
MAF bZIP transcription factor A
Subcellular Location
Nucleus.
Protein Name
Zinc finger protein Helios
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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