Anti-Carbonic Anhydrase I/CA1 Picoband® Antibody (monoclonal, 2B5) Fluoro488 Conjugated
Product Specifications
Background
Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene. It is a member of the Carbonic anhydrase. The CA1 gene is mapped to 8q22. CAI has got about 260 amino acids. This protein is highly expressed in erythrocytes. As catalysts of the reversible hydration of carbon dioxide, CAI participates in a variety of biologic processes like respiration, calcification, acid-base balance etc.
Synonyms
Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter; SLC2A1; GLUT1
Gene Name
CA1
Gene ID
759
UniProt
P00915
Host
Mouse
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CA1 recombinant protein (Position: D9-F261) . Human CA1 shares 78.5% and 81% amino acid (aa) sequence identity with mouse and rat CA1, respectively.
Clonality
Monoclonal
Clone
Clone: 2B5
Tissue Specificity
Detected in erythrocytes (at protein level) . Expressed at variable levels in many human tissues.
Applications
Flow Cytometry
Field of Research
Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
References & Citations
1. Lowe N, Edwards YH, Edwards M, Butterworth PH (Nov 1991) . Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8. Genomics 10 (4) : 882–8. 2. Entrez Gene: CA1 carbonic anhydrase I.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
46659 MW
Applications Notes
6
Gene Name Synonym
Solute carrier family 2 (facilitated glucose transporter), member 1
Subcellular Location
Cell membrane. Multi-pass membrane protein. Melanosome.
Protein Name
Isocitrate dehydrogenase [NADP] cytoplasmic
Isotype
Mouse IgG1
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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