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Anti-Liver Carboxylesterase 1/CES1 Antibody Picoband® (monoclonal, 3F10) Fluoro488 Conjugated

Selected Variant

M01741-1-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Synonyms

Fatty acid-binding protein, heart; Fatty acid-binding protein 3; Heart-type fatty acid-binding protein; H-FABP; Fabp3

Gene Name

CES1

Gene ID

1066

UniProt

P23141

Host

Mouse

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Liver Carboxylesterase 1/CES1 recombinant protein (Position: E99-A206) .

Clonality

Monoclonal

Clone

Clone: 3F10

Tissue Specificity

Heart, but also skeletal muscle, kidney, brain and mammary gland.

Applications

Flow Cytometry

Field of Research

Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Mesenchymal Stem Cells, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

References & Citations

1. Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1) . 2. Markey GM (Feb 2011) . Carboxylesterase 1 (Ces1) : from monocyte marker to major player. J Clin Pathol. 64 (2) : 107–9. 3. Zhu HJ, Appel DI, Johnson JA, Chavin KD, Markowitz JS (Jan 2009) . Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril. Biochem Pharmacol. 77 (7) : 1266–72.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Fatty acid binding protein 3

Subcellular Location

Cytoplasm.

Protein Name

Activating transcription factor 1

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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