Anti-Tspan1 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

TSPAN1 belongs to the large family of tetraspanins, so named because they contain 4 transmembrane domains. Tetraspanins are frequently expressed at the cell surface in association with each other and with other molecules, such as integrins (see ITGB1; 135630), and they function to regulate cell adhesion, migration, proliferation, and differentiation.

Synonyms

Transforming growth factor beta activator LRRC32; Garpin; Glycoprotein A repetitions predominant; GARP; Leucine-rich repeat-containing protein 32; LRRC32; D11S833E

Gene Name

Tspan1

Gene ID

298436

UniProt

Q6AYR9

Host

Rabbit

Reactivity

Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived rat Tspan1 recombinant protein (Position: A125-A212) .

Clonality

Polyclonal

Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas.

Applications

Flow Cytometry

Field of Research

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) . Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity) .

References & Citations

1. Serru, V., Dessen, P., Boucheix, C., Rubinstein, E. Sequence and expression of seven new tetraspans. Biochim. Biophys. Acta 1478: 159-163, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

Gene Name Synonym

Leucine rich repeat containing 32

Subcellular Location

Cell membrane. Single-pass type I membrane protein. Cell surface.

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

MBS9500391-01 1 Kit

MMP-1 Colorimetric Cell-Based ELISA Kit

View Details

MBS9500391-02 5x 1 Kit

MMP-1 Colorimetric Cell-Based ELISA Kit

View Details

GTR15081676 1 Vial

Lentiviral human HYOU1 shRNA (UAS) - Lentiviral human HYOU1 shRNA (UAS, iRFP) plasmid

View Details

E0014-HRP 100 µL

E2F4 Transcription Factor (HRP) discontinued

View Details

MBS3845553-01 10 mg

6-FAM SE

View Details

MBS3845553-02 25 mg

6-FAM SE

View Details

Anti-Tspan1 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Applications Notes

Gene Name Synonym

Subcellular Location

Isotype

Contents

Explore Other Products

MMP-1 Colorimetric Cell-Based ELISA Kit

MMP-1 Colorimetric Cell-Based ELISA Kit

Lentiviral human HYOU1 shRNA (UAS) - Lentiviral human HYOU1 shRNA (UAS, iRFP) plasmid

E2F4 Transcription Factor (HRP) discontinued

6-FAM SE

6-FAM SE