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Anti-SHISA6 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

The deduced 551-amino acid human SHISA6 protein has a domain structure typical of SHISA proteins, including an N-terminal signal peptide, followed by a cysteine-rich domain, a transmembrane domain, and a C-terminal proline-rich region. SHISA6 belongs to a SHISA subfamily containing SHISA7, SHISA8, and SHISA9. The SHISA6 gene is mapped to chromosome 17p12 based on an alignment of the SHISA6 sequence (GenBank AK127379) with the genomic sequence (GRCh38) .

Synonyms

Transmembrane protein 240; TMEM240; C1orf70

Gene Name

SHISA6

Gene ID

380702

UniProt

Q6ZSJ9

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SHISA6 recombinant protein (Position: K253-Y483) .

Clonality

Polyclonal

Tissue Specificity

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

References & Citations

1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/30/2017. 2. Pei, J., Grishin, N. V. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell. Signal. 24: 758-769, 2012.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

19908 MW

Applications Notes

6

Gene Name Synonym

Transmembrane protein 240

Subcellular Location

Cell junction, synapse . Cell membrane ; Multi-pass membrane protein .

Protein Name

Transmembrane protein 240

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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