Anti-Scn2a Antibody Picoband®

Navα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the SCN2A gene. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants.

Fatty acid-binding protein, heart; Fatty acid-binding protein 3; Heart-type fatty acid-binding protein; H-FABP; Mammary-derived growth inhibitor; MDGI; Muscle fatty acid-binding protein; M-FABP; FABP3; FABP11; MDGI

A synthetic peptide corresponding to a sequence at the N-terminus of mouse Scn2a, which shares 82.4% and 94.1% amino acid (aa) sequence identity with human and rat Scn2a, respectively.

Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Mesenchymal Stem Cells, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Redox Metabolism, Stem Cells

1. Ahmed, C. M. I., Ware, D. H., Lee, S. C., Patten, C. D., Ferrer-Montiel, A. V., Schinder, A. F., McPherson, J. D., Wagner-McPherson, C. B., Wasmuth, J. J., Evans, G. A., Montal, M. Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. Proc. Nat. Acad. Sci. 89: 8220-8224, 1992. 2. Ahmed, C. M. I., Ware, D. H., Lee, S. C., Patten, C. D., Ferrer-Montiel, A. V., Schinder, A. F., McPherson, J. D., Wagner-McPherson, C. B., Wasmuth, J. J., Evans, G. A., Montal, M. Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain. Proc. Nat. Acad. Sci. 89: 8220-8224, 1992. 3. Berkovic, S. F., Heron, S. E., Giordano, L., Marini, C., Guerrini, R., Kaplan, R. E., Gambardella, A., Steinlein, O. K., Grinton, B. E., Dean, J. T., Bordo, L., Hodgson, B. L., Yamamoto, T., Mulley, J. C., Zara, F., Scheffer, I. E. Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy. Ann. Neurol. 55: 550-557, 2004.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.