Anti-RAB1B Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene. Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi.
Synonyms
Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2
Gene Name
RAB1B
Gene ID
81876
UniProt
Q9H0U4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human RAB1B, which shares 100% and 96.8% amino acid (aa) sequence identity with mouse and rat RAB1B, respectively.
Clonality
Polyclonal
Tissue Specificity
Widely expressed in adult (at protein level) and fetal tissues.
Applications
Flow Cytometry
Field of Research
Hematopoietic Progenitors, Immunology, Innate Immunity, Stem Cells, Surface Molecules
Purification
Immunogen affinity purified.
Form
Liquid
Function
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
References & Citations
1. Alvarez, C., Garcia-Mata, R., Brandon, E., Sztul, E. COPI recruitment is modulated by a Rab1b-dependent mechanism. Molec. Biol. Cell 14: 2116-2127, 2003. 2. Chen, D., Guo, J., Gahl, W. A. RAB GTPases expressed in human melanoma cells. Biochim. Biophys. Acta 1355: 1-6, 1997. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 1/29/2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Thioredoxin 2
Subcellular Location
Mitochondrion.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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