Anti-METTL14 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene. METTL14 is part of a methyltransferase complex required for the common N6-methyladenosine (m6A) base modification that is enriched near stop codons and in long exons of mRNAs.
Synonyms
Mucin-20; MUC-20; MUC20; KIAA1359; UNQ2782/PRO7170
Gene Name
METTL14
Gene ID
57721
UniProt
Q9HCE5
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human METTL14 recombinant protein (Position: Q12-D350) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF) -induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 8/4/2015. 2. Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W., He, C. A METTL3-METTL14 complex mediates mammalian nuclear RNA N (6) -adenosine methylation. Nature Chem. Biol. 10: 93-95, 2014. 3. Nagase, T., Kikuno, R., Nakayama, M., Hirosawa, M., Ohara, O. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 273-281, 2000.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
108320 MW
Applications Notes
6
Gene Name Synonym
Mucin 20, cell surface associated
Subcellular Location
Apical cell membrane. Basolateral cell membrane. Microvillus membrane. Secreted.
Protein Name
Gamma-aminobutyric acid type B receptor subunit 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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