Anti-METTL1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
TRNA (guanine-N (7) -) -methyltransferase is an enzyme that in humans is encoded by the METTL1 gene. This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X.
Synonyms
Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7
Gene Name
METTL1
Gene ID
4234
UniProt
Q9UBP6
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human METTL1 recombinant protein (Position: A2-H276) .
Clonality
Polyclonal
Tissue Specificity
Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .
References & Citations
1. Bahr, A., Hankeln, T., Fiedler, T., Hegemann, J., Schmidt, E. R. Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation. Genomics 57: 424-428, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Interleukin 17B
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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