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Anti-Klrd1/CD94 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

Thrombospondin-2; THBS2; TSP2

Gene Name

Klrd1

Gene ID

16643

UniProt

O54707

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Klrd1/CD94 recombinant protein (Position: N33-I179) .

Clonality

Polyclonal

Tissue Specificity

High expression in invertebral disk tissue.

Applications

Flow Cytometry

Field of Research

Calcium Signaling, Calmodulin Pathway, Cardiovascular, Hypertrophy, Neuroscience, Neurotransmission, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

References & Citations

1. Braud, V. M., Allan, D. S. J., O'Callaghan, C. A., Soderstrom, K., D'Andrea, A., Ogg, G. S., Lazetic, S., Young, N. T., Bell, J. I., Phillips, J. H., Lanier, L. L., McMichael, A. J. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391: 795-799, 1998. 2. Chang, C., Rodriguez, A., Carretero, M., Lopez-Botet, M., Phillips, J. H., Lanier, L. L. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Europ. J. Immun. 25: 2433-2437, 1995. 3. Lazetic, S., Chang, C., Houchins, J. P., Lanier, L. L., Phillips, J. H. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immun. 157: 4741-4745, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Thrombospondin 2

Subcellular Location

Synapse. Postsynaptic density. Dendritic spine. Dendrite.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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