Anti-Kir6.1/KCNJ8 Antibody Picoband®

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS) .

Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. .

1. Barajas-Martinez, H., Hu, D., Ferrer, T., Onetti, C. G., Wu, Y., Burashnikov, E., Boyle, M., Surman, T., Urrutia, J., Veltmann, C., Schimpf, R., Borggrefe, M., Wolpert, C., Ibrahim, B. B., Sanchez-Chapula, J. A., Winters, S., Haissaguerre, M., Antzelevitch, C. Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm 9: 548-555, 2012. 2. Beltrame, J. F., Sasayama, S., Maseri, A. Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. J. Am. Coll. Cardiol. 33: 1442-1452, 1999. 3. Brownstein, C. A., Towne, M. C., Luquette, L. J., Harris, D. J., Marinakis, N. S., Meinecke, P., Kutsche, K., Campeau, P. M., Yu, T. W., Margulies, D. M., Agrawal, P. B., Beggs, A. H. Mutation of KCNJ8 in a patient with Cantu syndrome with unique vascular abnormalities: support for the role of K (ATP) channels in this condition. Europ. J. Med. Genet. 56: 678-682, 2013.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.