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Anti-IL-21/Il21 Antibody Fluoro647 Conjugated

Product Specifications

Background

Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

Beta-2-microglobulin; B2m

Gene Name

Il21

Gene ID

60505

UniProt

Q9ES17

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse IL-21/Il21 recombinant protein (Position: H18-S146) .

Clonality

Polyclonal

Tissue Specificity

Detected in lung, spleen, uterus, vagina and epididymis. .

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system.

References & Citations

1. Berglund, L. J., Avery, D. T., Ma, C. S., Moens, L., Deenick, E. K., Bustamante, J., Boisson-Dupuis, S., Wong, M., Adelstein, S., Arkwright, P. D., Bacchetta, R., Bezrodnik, L., and 12 others. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood 122: 3940-3950, 2013. 2. Brandt, K., Singh, P. B., Bulfone-Paus, S., Ruckert, R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 18: 223-232, 2007. 3. Brodeur, T. Y., Robidoux, T. E., Weinstein, J. S., Craft, J., Swain, S. L., Marshak-Rothstein, A. IL-21 promotes pulmonary fibrosis through the induction of profibrotic CD8+ T cells. J. Immun. 195: 5251-5260, 2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00459-1-Fluoro647

Calculated Molecular Weight

22875 MW

Applications Notes

6

Gene Name Synonym

Beta-2 microglobulin

Subcellular Location

Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Protein Name

Neutrophil gelatinase-associated lipocalin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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