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Anti-FEZF1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

FEZ family zinc finger 1 is a protein that in humans is encoded by the FEZF1 gene. This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants.

Synonyms

One cut domain family member 2; Hepatocyte nuclear factor 6-beta; HNF-6-beta; One cut homeobox 2; Transcription factor ONECUT-2; OC-2; ONECUT2; HNF6B

Gene Name

FEZF1

Gene ID

389549

UniProt

A0PJY2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human FEZF1 recombinant protein (Position: A45-K258) .

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Applications

Flow Cytometry

Field of Research

Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

References & Citations

1. Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., Hibi, M. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development 133: 3993-4004, 2006. 2. Kotan, L. D., Hutchins, B. I., Ozkan, Y., Demirel, F., Stoner, H., Cheng, P. J., Esen, I., Gurbuz, F., Bicakci, Y. K., Mengen, E., Yuksel, B., Wray, S., Topaloglu, A. K. Mutations in FEZF1 cause Kallmann syndrome. Am. J. Hum. Genet. 95: 326-331, 2014. 3. Song, I.-S., Oh, N. S., Kim, H.-T., Ha, G.-H., Jeong, S.-Y., Kim, J.-M., Kim, D.-I., Yoo, H.-S., Kim, C.-H., Kim, N.-S. Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene. Cancer Res. 69: 3131-3139, 2009. Note: Erratum: Cancer Res. 69: 4092 only, 2009.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

One cut homeobox 2

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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