Anti-CEBP Delta/CEBPD Antibody Picoband®

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11.

Calpain-2 catalytic subunit;3.4.22.53; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; Millimolar-calpain; M-calpain; CAPN2; CANPL2

Calcium Signaling, Cancer, Cancer Metabolism, Cell Biology, Metabolism, Metabolism Processes, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Signal Transduction, Signaling Pathway

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508) . .

1. Barbaro, V., Testa, A., Di Iorio, E., Mavilio, F., Pellegrini, G., De Luca, M. C/EBP-delta regulates cell cycle and self-renewal of human limbal stem cells. J. Cell Biol. 177: 1037-1049, 2007. 2. Cleutjens, C. B. J. M., van Eekelen, C. C. E. M., van Dekken, H., Smit, E. M. E., Hagemeijer, A., Wagner, M. J., Wells, D. E., Trapman, J. The human C/EBP-delta (CRP3/CELF) gene: structure and chromosomal localization. Genomics 16: 520-523, 1993. 3. Gigliotti, A. P., Johnson, P. F., Sterneck, E., DeWille, J. W. Nulliparous CCAAT/enhancer binding protein-delta (C/EBP-delta) knockout mice exhibit mammary gland ductal hyperlasia (sic) . Exp. Biol. Med. 228: 278-285, 2003.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.