Anti-CACNA1S Antibody Picoband® Fluoro550 Conjugated

Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.

Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.

1. Boerman, R. H., Ophoff, R. A., Links, T. P., van Eijk, R., Sandkuijl, L. A., Elbaz, A., Vale-Santos, J. E., Wintzen, A. R., van Deutekom, J. C., Isles, D. E., Fontaine, B., Padberg, G. W., Frants, R. R. Mutation in DHP receptor alpha-1 subunit (CACLN1A3) (sic) gene in a Dutch family with hypokalaemic periodic paralysis. J. Med. Genet. 32: 44-47, 1995. 2. Campbell, K. P., Leung, A. T., Sharp, A. H. The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. Trends Neurosci. 11: 425-430, 1988. 3. Catterall, W. A. Functional subunit structure of voltage-gated calcium channels. Science 253: 1499-1500, 1991.