Anti-CACNA1S Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Cav1.1 also known as the calcium channel, voltage-dependent, L type, alpha 1S subunit, (CACNA1S), is a protein which in humans is encoded by the CACNA1S gene. This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.
Synonyms
Endoglin; Cell surface MJ7/18 antigen; CD105; Eng; Edg
Gene Name
CACNA1S
Gene ID
779
UniProt
Q13698
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CACNA1S recombinant protein (Position: E1583-C1779) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.
References & Citations
1. Boerman, R. H., Ophoff, R. A., Links, T. P., van Eijk, R., Sandkuijl, L. A., Elbaz, A., Vale-Santos, J. E., Wintzen, A. R., van Deutekom, J. C., Isles, D. E., Fontaine, B., Padberg, G. W., Frants, R. R. Mutation in DHP receptor alpha-1 subunit (CACLN1A3) (sic) gene in a Dutch family with hypokalaemic periodic paralysis. J. Med. Genet. 32: 44-47, 1995. 2. Campbell, K. P., Leung, A. T., Sharp, A. H. The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. Trends Neurosci. 11: 425-430, 1988. 3. Catterall, W. A. Functional subunit structure of voltage-gated calcium channels. Science 253: 1499-1500, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Endoglin
Subcellular Location
Membrane; Single-pass type I membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
