Anti-BHMT Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst (e) inemia, but such a defect has not yet been observed.
Synonyms
Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR
Gene Name
BHMT
Gene ID
635
UniProt
Q93088
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human BHMT recombinant protein (Position: E80-Q406) .
Clonality
Polyclonal
Tissue Specificity
Brain.
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, ECM Proteins, Neuroscience
Purification
Immunogen affinity purified.
Form
Liquid
Function
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
References & Citations
1. Garrow, T. A. Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J. Biol. Chem. 271: 22831-22838, 1996. 2. Li, F., Feng, Q., Lee, C., Wang, S., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Wieben, E. D., Schaid, D. J., Yee, V., Weinshilboum, R. M. Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization. Molec. Genet. Metab. 94: 326-335, 2008. 3. Park, E. I., Garrow, T. A. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J. Biol. Chem. 274: 7816-7824, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Neurocan
Subcellular Location
Secreted .
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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