Anti-OTULIN Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1 (Met1) -linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients.
Synonyms
Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; GPD1L; KIAA0089
Gene Name
OTULIN
Gene ID
90268
UniProt
Q96BN8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human OTULIN recombinant protein (Position: A49-L352) .
Clonality
Polyclonal
Tissue Specificity
Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD (H) balance induced by DPD1L.
References & Citations
1. Damgaard, R. B., Walker, J. A., Marco-Casanova, P., Morgan, N. V., Titheradge, H. L., Elliott, P. R., McHale, D., Maher, E. R., McKenzie, A. N. J., Komander, D. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell 166: 1215-1230, 2016. 2. Gross, M. B. Personal Communication. Baltimore, Md. 3/25/2014. 3. Heger, K., Wickliffe, K. E., Ndoja, A., Zhang, J., Murthy, A., Dugger, D. L., Maltzman, A., de Sousa E Melo, F., Hung, J., Zeng, Y., Verschueren, E., Kirkpatrick, D. S., and 10 others. OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature 559: 120-124, 2018.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
49229 MW
Applications Notes
6
Gene Name Synonym
Glycerol-3-phosphate dehydrogenase 1 like
Subcellular Location
Cytoplasm.
Protein Name
Chromaffin granule amine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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