Anti-KCNJ16 Antibody Picoband® Fluoro488 Conjugated

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the Kir5.1 protein. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene.

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

1. D'Adamo, M. C., Shang, L., Imbrici, P., Brown, S. D. M., Pessia, M., Tucker, S. J. Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity. J. Biol. Chem. 286: 192-198, 2011. 2. Derst, C., Karschin, C., Wischmeyer, E., Hirsch, J. R., Preisig-Muller, R., Rajan, S., Engel, H., Grzeschik, K.-H., Daut, J., Karschin, A. Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. FEBS Lett. 491: 305-311, 2001. 3. Liu, Y., McKenna, E., Figueroa, D. J., Blevins, R., Austin, C. P., Bennett, P. B., Swanson, R. The human inward rectifier K+ channel subunit Kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. Cytogenet. Cell Genet. 90: 60-63, 2000.