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Anti-IGF2-AS Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD) . Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants.

Synonyms

Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a; TIMM17A; MIMT17; TIM17; TIM17A; TIMM17

Gene Name

IGF2-AS

Gene ID

51214

UniProt

Q6U949

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human IGF2-AS recombinant protein (Position: M1-K168) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Cancer, Metabolism, Mitochondrial Metabolism, Organelle Proteins, Pathways and Processes, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

References & Citations

1. Bachner-Melman, R., Zohar, A. H., Nemanov, L., Heresco-Levy, U., Gritsenko, I., Ebstein, R. P. Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study. Am. J. Psychiat. 162: 2256-2262, 2005. 2. Bartholdi, D., Krajewska-Walasek, M., Ounap, K., Gaspar, H., Chrzanowska, K. H., Ilyana, H., Kayserili, H., Lurie, I. W., Schinzel, A., Baumer, A. Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS) : results from a large cohort of patients with SRS and SRS-like phenotypes. (Letter) J. Med. Genet. 46: 192-197, 2009. 3. Begemann, M., Zirn, B., Santen, G., Wirthgen, E., Soellner, L., Buttel, H.-M., Schweizer, R., van Workum, W., Binder, G., Eggermann, T. Paternally inherited IGF2 mutation and growth restriction. New Eng. J. Med. 373: 349-356, 2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Translocase of inner mitochondrial membrane 17A

Subcellular Location

Mitochondrion inner membrane, Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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