Anti-IGF2-AS Antibody Picoband®

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD) . Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants.

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

1. Bachner-Melman, R., Zohar, A. H., Nemanov, L., Heresco-Levy, U., Gritsenko, I., Ebstein, R. P. Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study. Am. J. Psychiat. 162: 2256-2262, 2005. 2. Bartholdi, D., Krajewska-Walasek, M., Ounap, K., Gaspar, H., Chrzanowska, K. H., Ilyana, H., Kayserili, H., Lurie, I. W., Schinzel, A., Baumer, A. Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS) : results from a large cohort of patients with SRS and SRS-like phenotypes. (Letter) J. Med. Genet. 46: 192-197, 2009. 3. Begemann, M., Zirn, B., Santen, G., Wirthgen, E., Soellner, L., Buttel, H.-M., Schweizer, R., van Workum, W., Binder, G., Eggermann, T. Paternally inherited IGF2 mutation and growth restriction. New Eng. J. Med. 373: 349-356, 2015.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.