Anti-GNG2 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Guanine nucleotide-binding protein G (I) /G (S) /G (O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene. This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules.
Synonyms
Aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; AKR7A2; AFAR; AFAR1; AKR7
Gene Name
GNG2
Gene ID
54331
UniProt
P59768
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GNG2 recombinant protein (Position: A2-D48) .
Clonality
Polyclonal
Tissue Specificity
Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
Applications
Flow Cytometry
Field of Research
Epigenetics and Nuclear Signaling, Pol II Transcription, Polymerase Associated Factors, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB) . Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro) . Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro) . Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
References & Citations
1. Downes, G. B., Gilbert, D. J., Copeland, N. G., Gautam, N., Jenkins, N. A. Chromosomal mapping of five mouse G protein gamma subunits. Genomics 57: 173-176, 1999. 2. Modarressi, M. H., Taylor, K. E., Wolfe, J. Cloning, characterization, and mapping of the gene encoding the human G protein gamma-2 subunit. Biochem. Biophys. Res. Commun. 272: 610-615, 2000. 3. Wolfe, J. T., Wang, H., Howard, J., Garrison, J. C., Barrett, P. Q. T-type calcium channel regulation by specific G-protein beta-gamma subunits. Nature 424: 209-213, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
87148 MW
Applications Notes
6
Gene Name Synonym
Aldo-keto reductase family 7 member A2
Subcellular Location
Golgi apparatus. Cytoplasm.
Protein Name
ADAM metallopeptidase domain 28
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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